7 Pre-Workout Supplements

Maximize Your Workout with These Pre-Workout Supplements

In a few previous posts, I discussed post-workout nutrition and supplement needs. Post-workout is a critical time period when it comes to ensuring your hard work in the gym doesn’t go to waste. Getting the right nutrients post-workout kickstarts recovery, enables the muscle building process, and ensures we maintain the lean muscle we have spent hours in the gym putting on. But did you know that supplementing with the right nutrients pre-workout not only helps you get the most out of your workout, it will also enable you to work out at a higher intensity, push out more weight, increase your time to failure, increase your power output, and allow you to train longer? This can ultimately lead to superior workouts and better results!


If you have not been supplementing pre-workout, maybe now is the time to start. Try one or all of these seven research-proven, pre-workout supplements to make the most of your time in the gym! Most of these supplements can be found in a blended pre-workout product, but can also be used on their own. For maximum results, be sure to take 15 to 30 minutes before to your workout!



Most women who are serious about lifting have tried this one. In fact, of all the supplements on the market today, creatine is by far the most researched and effective. Supplementing with creatine increases the body’s creatine stores. As a result, more phosphocreatine is available for use by our muscles, which means more phosphate is available to ADP to help regenerate ATP– our muscles’ energy source. Supplementing with creatine not only results in longer sets and more reps, but also gains in lean muscle and strength. One downside of creatine is that it can sometimes cause bloating and water retention– two things most women do not want to experience from a supplement! Water is needed for transport of creatine into the muscle cells, and can therefore cause increased water retention in the body. Try using a daily dose of 3 grams per day over a 4- to 6-week period. And perhaps reserve creatine use for the off-season or muscle-building phase, to avoid unnecessary water retention come contest or bikini season!



Beta-alanine is a non-essential, amino acid that can increase the level of carnosine in the muscle. Research has shown that when beta-alanine is consumed, it enters the bloodstream and is taken up by the muscle cells, where it is synthesized with the abundant amino acid L-histidine to form the dipeptide, carnosine. The primary function of intramuscular carnosine is to buffer hydrogen ions (H+), which can get produced during an intense workout. Carnosine neutralizes or buffers acidic build-up in the muscles by locking up these hydrogen ions and thereby increasing time to fatigue, allowing you to push through longer sets and making those last few reps possible. Beta-alanine comes with a unique side effect, often termed as a “burning-rush,” but not experienced by everyone, and is typically dose dependent. Research has also shown that combining beta-alanine with creatine can result in more increases in lean mass, more loss of body fat, and greater maximum strength lifts when compared to supplementing with just creatine alone. A typical dose of beta-alanine is 1.6 grams per serving.



An amino acid that the body cannot make naturally, arginine is involved in many processes including hormone secretion, the removal of toxic waste products, improving sexual function and immune defense. But perhaps the best use of arginine for a serious fitness athlete is its ability to produce nitric oxide (NO) through the property of vasodilatation. Supplementing with arginine can help increase vasodilatation of blood vessels, resulting in better transfer of important nutrients to the muscle, and ultimately aiding in growth and repair.  This increased dilation and delivery results in that muscle “pump” you may experience during a workout. Arginine can be supplemented at about 500 mg to 1000 mg for best results.


Citrulline Malate

Citrulline is a non-essential amino acid that has a few different roles relative to maximizing your workouts! During an intense workout, metabolic breakdown of amino acids, increased levels of ammonia, toxic nitrogen metabolites and limited arginine availability can occur. Supplementation with citrulline malate can also increase arginine levels. And as just discussed, increasing levels of arginine increases the amount of NO available to the muscles! Citrulline malate can also assist in the elimination of byproducts of protein metabolism, reduce the negative effects of ammonia, and can help eliminate that lactic acid burn experienced during extreme workouts, therefore assisting with its anti-fatigue properties and reduced muscle soreness. Research has also shown that supplementation with citrulline malate can increase anaerobic energy production, resulting in an increased number of reps per set and can also increase aerobic energy production by increasing the rate of muscle ATP production during exercise. That means more energy is available to working muscles from both of these pathways, allowing you to go the distance during every workout!



This energy-boosting compound is by far the most commonly used pre-workout product on this list. Caffeine is contained in everything from coffee, tea and chocolate to energy drinks. You have probably already relied on caffeine’s energizing effects to get you through a long day at work, study for a tough exam or even lift you up prior to a tough workout. Caffeine works by inhibiting the enzyme that blocks degradation of cAMP, thus prolonging the presence of epinephrine. This mechanism of action allows energy levels to remain high for pro-long periods, which can mean longer workouts! In addition, caffeine can increase the activity of neurotransmitters involved in focus and response.  Typical dose of caffeine is between ~100 to 200 mg, and is dependent on your caffeine sensitivity.


This non-essential amino acid was previously mentioned as an energy supplement, because of its ability to improve perceived level of fatigue, cognitive and physical performance during stressful conditions. This is also a great supplement to take pre-workout for the very same reasons. Tyrosine’s benefits including improved mental alertness, increased reaction speed, and increased ability to concentrate are all beneficial whether you are performing a tough workout, a CrossFit session, or a long and strenuous cardio session. Tyrosine can help you get through with increased focused and concentration. Try supplementing with a dose of tyrosine between 500 to 1000 mg per day prior to workouts.


Vitamin B6 and B12

Vitamin B6 and B12 are the most commonly supplemented B-vitamins primarily for their ability to influence the energy pathways. B6 is highly involved in protein metabolism by aiding in the manufacturing of amino acids, which is critical to the muscle building pathway. It is also involved in carbohydrate utilization. Research has shown that athletes have an increased need for vitamin B6 and that performance can be improved with supplementation. Vitamin B12 is involved in carbohydrate metabolism and maintaining nerve cell transmission which is fundamental for muscle contraction, coordination and muscle growth. It is also involved in the metabolism of every cell in the body, especially affecting DNA synthesis and regulation, fatty acid synthesis and energy production.



Artjoli GG, Gualano B, Smith A, Stout J, Lancha A. (2010). Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc 42(6): 1162-73.

Bendahan D, Mattei J, Ghattas B, Confort-Gouny S, Le Guern M, Cozzone P. (2002). Citrulline malate promoties aerobic energy production in human exercising muscle. Br J Sports Med. 36(4): 282-9.

Deijen JB, et al. 1999. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Research Bulletin. 48(2): 203-209.

Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J. (2006). Effect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes. Int J Sports Nutr Exerc Metab. 16(4): 430-46.

Hoffman J, Ratamess N, Faigenbaum A, Ross R, Kang J, Stout J, Wise J. (2008). Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Nutr Res. 28(1): 31-5.

Janeira MA, Maia JR, Santos PJ. (1998). Citrulline malate effects on the aerobic-anaerobic threshold and in post-exercise blood lactate recovery. Med Sci Sports Exer. 30(5): 880s.

Kilduff LP, Vidakovic P, et al. (2002). Effects of creatine on isometric bench press performance in resistance-trained humans. Med Sci Sports Exerc. 34(7): 1176-83.

Kreider, R., Ferreira, M., Wilson, M., Grindstaff, P., Plisk, S., & Reinhardy, J. et al. (1998). Effects of creatine supplementation on body composition, strength and sprint performance. Med Sci Sport Exerc, 30, 73–82.

Perez-Guisado J, Jakeman P. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 24(5): 1215-22.

Spriet LL. 1995. Caffeine and Performance. International Journal of Sport Nutrition. 5S: S84-99.

Tarnopolsky MA. 1994. Caffeine and endurance performance. Sports Med. 18(2): 109-25.

Volek JS, Rawson ES. (2003). Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 17(4): 822-31.

Williams MH. 2004. Dietary Supplements and Sports Performance: Introduction and Vitamins. Journal of the International Society of Sports Nutrition. 1(2):1-6.

Lauren Jacobsen

Lauren is the creator of Sexy, Strong and Fit Online Coaching Services specializing in transforming women to fitness model condition. Lauren has over 15 years of experience as a trainer, supplement consultant and nutrition expert. She is also the TV show host of "Body Fuel," a competitive athlete and regular contributor to various fitness publications.

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